Genetic Studies in Male Infertility

Infertility is defined as the inability to have children despite regular and unprotected sexual intercourse for at least one year. This time, which is determined as one year, can also be accepted as 2 years after taking into account different factors such as changes in living conditions and working conditions.

What Are the Symptoms of Infertility in Men?

There are no specific symptoms of infertility, and on top of that, having unprotected sexual intercourse regularly and not having a child within 1 or 2 years can be considered as a sign of infertility. However, some additional symptoms may occur depending on the disease that can cause male infertility. If these symptoms are not directly in the testicles, it is very unlikely that the patient will associate them with infertility. However, pain and swelling in the testicles; Findings such as penile discharge may also be a sign of infertility, and may be a great warning to the patient.

What are the Causes of Infertility in Men?

One third of infertility reasons are for men, the other one third is for women and the remaining one third is for both male and female reasons. Naturally, male factors, which are almost 50% - 60%, may play a role.

With the male reproductive system, male reproduction basically starts from the hypothalamus region, which is located in the lower parts of the brain. Again, it continues with the pituitary gland located in the lower parts of the brain in the head and ends in the testicles. It should be able to evaluate the causes of infertility by dividing it into sections according to these regions, namely the anatomical localization of the reproductive system.

Sexually Transmitted Diseases and Infertility

Untreated and untreated sexually transmitted diseases can be caused by infertility from time to time. If gonorrhea, which usually occurs in the lumbar region, is not treated, it can lead to obstructive azoospermia, which causes obstruction in the sperm ducts, and also sexually transmitted diseases, which cause the continuous presence of inflammatory cells in the sperm canals and thus the deterioration of sperm quality, which causes the formation of toxic substances on the sperm. causes an increase in sperm DNA damage.

Do Sexual Dysfunctions Cause Infertility?

Sexual dysfunction can also cause infertility. If the reason is not successful sexual intercourse, then a successful procedure will not take place, and thus, it is very difficult for a man who does not have sexual intercourse to have a child and reproduction cannot be expected. There are also different opinions about the great effects of the drugs used for these reasons on sperm function. For these reasons, people with limited sperm count should get a specialist doctor's advice before using the drug.

Male Infertility Treatment

The treatment process changes according to the infertility of the sick person and its cause, and whether there is sperm in the semen or not. If there is a treatable condition, it should be corrected first.

Causes of Sperm DNA Disorder

• Certain diseases
• Drug use
• High fever
• Increased testicular temperature
• Air pollution
• Cigarette
• Eld
• Varicocele

What is Sperm DNA Damage?

Sperm analysis is very insufficient to show the major problems (mostly DNA damage) of some sperms. Normal levels of sperm analysis are seen in 15% of patients with male infertility. There is a strong and severe association between the deterioration of the normal structure of the sperm in the genetic structure and infertility.

The DNA structure of the sperm is very important in order to obtain a quality embryo with fertilization. Sperm DNA contains a very specifically tight and rigidly packed chromatin network. Being tightly packed also plays a very important role in the transfer of genetic information to the egg. Although some genes are also expressed, it does not prevent the creation of physical and chemical substances, which are necessary for embryo development. Healthy and smooth sperm DNA is stable and can transfer its DNA through fertilization.